Pharmacokinetic Studies of Radiopharmaceuticals

Pharmacokinetic (PK) studies of radiopharmaceuticals (RPs) are distinctive because small concentrations active ingredients. Whereas methods applicable to non-RP medicinal products cannot be used for RPs, radionuclide can provide an insight into behaviour. The aim the study was compare approaches pre-clinical PK evaluation RPs and other products. article describes main aspects non-RPs, defining similarities differences in conduction these studies. authors provided examples from their own RPs: one investigating possibility using 99m Tc–Zoledronic acid visualise bone pathologies patients receiving Zometa © ; demonstrating advantage orthotopic xenograft models over heterotopic ones. According conclusions, based on ionising radiation undeniably superior (for example, former offer a non-invasive detection ingredients nano and/or pico range). data obtained during characterise both safety functional suitability RPs.